Charles, Duke of Guise

Charles of Lorraine, 4th Duke of Guise (20 August 1571 – 30 September 1640) was the son of Henry I, Duke of Guise and Catherine of Cleves, and succeeded his father as Duke of Guise in 1588. Initially part of the Catholic league, he pledged his support for Henry IV of France and was made Admiral of the Levant by Louis XIII of France. After siding with the Queen mother, Marie de' Medici, against Cardinal Richelieu, he fled to Italy with his family where he died in 1640.

Marriage
On 6 January 1611 he married Henriette Catherine de Joyeuse.

Issue
Knight of the Order of Malta, died of fever at Cambrai and buried near his ancestors at Joinville.
 * 1) François (3 April 1612 – 7 December 1639), Prince of Joinville who died in Florence during the family's exile.
 * 2) Twin boys (4 March 1613 – 19 March 1613)
 * 3) Henry II, Duke of Guise (1614–1664), Archbishop of Reims.
 * 4) Marie, Duchess of Guise (1615–1688)
 * 5) A girl, called Mademoiselle de Joinville (4 March 1617 – 18 January 1618)
 * 6) Charles Louis (15 July 1618 – 15 March 1637)
 * 7) Françoise Renée (10 January 1621 – 4 December 1682, Montmartre), Abbess of Montmartre.
 * 8) Louis, Duke of Joyeuse (1622–1654)
 * 9) Roger (21 March 1624 – died 9 September 1653) called the Chevalier de Joinville and later the Chevalier de Guise,