Virginia de' Medici

Virginia de' Medici (29 May 1568 – 15 January 1615) was an Italian princess, a member of the House of Medici and by marriage Duchess of Modena and Reggio. Regent of the Duchy of Modena and Reggio in 1601 during the absence of her husband, she was able to protect the autonomy of the city of Modena from the attacks of the local Podestà and Judge. Her husband's infidelities increased her already erratic behaviour and led to a permanent mental illness, which lasted until her death.

Issue

 * 1) Giulia d'Este (1588–1645) never married.
 * 2) Alfonso III d'Este, Duke of Modena (1591–1644), father of Francesco I d'Este, Duke of Modena.
 * 3) Laura d'Este (1594–1630) married Alessandro Pico, Duke of Mirandola and had issue.
 * 4) Luigi d'Este, Laird o Montecchio and Scandiano (1593/1594–1664) had issue.
 * 5) Caterina d'Este (1595–1618) never married.
 * 6) Ippolito d'Este (1599–1647) never married.
 * 7) Niccolo d'Este (1601–1640) married Sveva d'Avalos but had no issue.
 * 8) Borso d'Este (1605–1657) married his niece Ippolita d'Este and had issue (including Maria Angela Caterina d'Este)
 * 9) Foresto d'Este (1606–1639/1640)
 * 10) Angela Caterina d'Este (died 1651) nun.