Cosimo I de' Medici, Grand Duke of Tuscany

Cosimo I de' Medici (12 June 1519 – 21 April 1574) was the second Duke of Florence from 1537 until 1569, when he became the first Grand Duke of Tuscany, a title he held until his death.

Children

 * 1) Maria de' Medici (3 April, 1540 – 19 November, 1557) engaged to Alfonso II d'Este, Duke of Ferrara, but died before marriage.
 * 2) Francesco de' Medici (25 March, 1541 – 19 October, 1587): Succeeded his father as Grand Duke of Tuscany and married Joanna of Austria and had children before he married his mistress, Bianca Cappello and had further children.
 * 3) Isabella de' Medici (31 August 1542 – 16 July 1576): married, Paolo Giordano I Orsini, Duke of Bracciano but had no children.
 * 4) Giovanni de' Medici (28 September 1543 – November 1562): Became Bishop of Pisa and cardinal.
 * 5) Lucrezia de' Medici (7 June 1545 – 21 April 1561) married Alfonso II d'Este, Duke of Ferrara.
 * 6) Pietro (10 August 1546 – 10 June 1547) Died in infancy.
 * 7) Garzia de' Medici (5 July 1547 – 12 December 1562) died young.
 * 8) Antonio de' Medici (1 July, 1548 – July 1548): died in infancy.
 * 9) Ferdinando I de' Medici, Grand Duke of Tuscany (30 July 1549 – 17 February 1609): Succeeded his brother as Grand Duke of Tuscany and married Christina of Lorraine and had children.
 * 10) Anna (19 March 1553 – 6 August 1553): Died in infancy.
 * 11) Pietro de' Medici (3 June 1554 – 25 April 1604) Murdered his wife and cousin, Eleonora di Garzia di Toledo.